oprD Genes Detected in Pseudomonas aeruginosa Isolates from a Teaching Hospital but Lost in a Carbapenem-Resistant Strain
نویسندگان
چکیده
منابع مشابه
Carbapenem and Fluoroquinolone Resistance in Multidrug Resistant Pseudomonas aeruginosa Isolates from Al-Zahra Hospital, Isfahan, Iran
Introduction: The major resistance mechanisms of Pseudomonas aeruginosa to fluoroquinolones and carbapenems are associated with the mutations in the genes gyrA and oprD encoding type II topoisomerases (DNA gyrase) and OprD porin, respectively. Method: In this cross-sectional study, sixty five clinical samples were collected from patients hospitalized in Al-Zahra Hospital of Isfahan, Iran. Susce...
متن کاملInvestigation of OprD Porin Protein Levels in Carbapenem-Resistant Pseudomonas aeruginosa Isolates.
BACKGROUND The Pseudomonas aeruginosa porin OprD is a substrate-specific porin that facilitates the diffusion of basic amino acids, small peptides, and carbapenems into the cell. OprD-mediated resistance occurs as a result of decreased transcriptional expression of oprD and/or loss of function mutations that disrupt protein activity. OBJECTIVES In this study, we examined the level of oprD exp...
متن کاملcarbapenem and fluoroquinolone resistance in multidrug resistant pseudomonas aeruginosa isolates from al-zahra hospital, isfahan, iran
introduction: the major resistance mechanisms of pseudomonas aeruginosa to fluoroquinolones and carbapenems are associated with the mutations in the genes gyra and oprd encoding type ii topoisomerases (dna gyrase) and oprd porin, respectively. method: in this cross-sectional study, sixty five clinical samples were collected from patients hospitalized in al-zahra hospital of isfahan, iran. susce...
متن کاملinvestigation of oprd porin protein levels in carbapenem-resistant pseudomonas aeruginosa isolates
conclusions although the data support the idea that the basic mechanism of imipenem resistance could be via the loss of oprd, they do not fully explain the role of oprd and indicate that other mechanisms may play an important role. additionally, the significant decrease in the oprd levels in mdr strains suggests that oprd also plays a role in the emergence of both carbapenem and non-carbapenem ...
متن کاملCarbapenem-resistant Pseudomonas aeruginosa outbreak in an intensive care unit of a teaching hospital.
The genetic similarity of carbapenem-resistant Pseudomonas aeruginosa strains isolated in the Hospital Universitário São Francisco, Bragança Paulista, São Paulo, Brasil, was evaluated by pulsed field gel electrophoresis (PFGE). A unique clone was detected among 5 of 7 isolates, suggesting that cross-contamination might have played a role in the spread of carbapenem-resistant P. aeruginosa strai...
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ژورنال
عنوان ژورنال: Journal of Advances in Medicine and Medical Research
سال: 2019
ISSN: 2456-8899
DOI: 10.9734/jammr/2019/v29i930122